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KMID : 0895820130230030001
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Journal of Oriental Rehabilitation Medicine
2013 Volume.23 No. 3 p.1 ~ p.14
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Effects of Samki-eum (s?nqi-y?n) on Freund’s Complete Adjuvant-induced Arthritic Rats
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Choi Eun-Sill
Jang Hong-Gye
Kwon O-Gon
Woo Chang-Hoon
An Hee-Duk
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Abstract
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Objectives : The object of this study was to observe the favorable anti-arthritic effects of Samki-eum (sanqi-yin) on Freund`s complete adjuvant (FCA)-induced arthritic Wistar rats.
Methods : Rheumatoid arthritis was induced by intradermal injection of FCA, and 300, 150 or 750 mg/kg of Samki-eum sanqi-yin) were orally administered once a day for 14 days from 14 days after FCA treatments, and 15 mg/kg of dexamethasone was intraperitoneally administered as reference drug in this experiment. All rats were sacrificed at 14 days after continuous oral treatment of Samki-eum (sanqi-yin) or intraperitoneal administration of dexamethasone, and changes on the body weight, knee circumferences, gross arthritis score, inflammatory tissue prostaglandin (PG) E2 levels were monitored with cartilage collagen components and glucosaminoglycans compositions - chondroitin sulphate, heparan sulphate and hyaluronic acid in the present study.
Results : As results of FCA treatment, classic rheumatoid arthritis featuring dramatical decreases on the body weights, cartilage collagen contents and bone glucosaminoglycans-chondroitin sulphate, heparan sulphate and hyaluronic acid contents, with increases on the knee circumferences, gross arthritis scores and inflammatory tissue PGE2 levels. However, these changes from FCA-induced rheumatoid arthritis were clearly reduced by treatment of dexamethasone and both two different dosages of Samki-eum (sanqi-yin) 300 and 150 mg/kg in the present study. Although FCA-induced arthritis were more favorably inhibited by treatment of dexamethasone 15 mg/kg as compared with Samki-eum (sanqi-yin) 300 mg/kg, marked decreases of body weights were detected in dexamethasone 15 mg/kg treated rats, and Samki-eum (sanqi-yin) 300 mg/kg showed similar preserve effects on the cartilage glucosaminoglycan compositions in this study. ]
Conclusions : The results obtained in this study suggest that over 300 and 150 mg/kg of Samki-eum (sanqi-yin) showed favorable anti-arthritic effects on the FCA-induced arthritis mediated by suppression of PGE2, a inflammatory mediator. However, detail mechanism studies should be conduced in future with the screening of the biological active compounds in this herb. Although overall anti-inflammatory effects Samki-eum (sanqi-yin) 300 mg/kg were lowered than those of dexamethasone 15 mg/kg treated rats, Samki-eum (sanqi-yin) 300 mg/kg treated rats showed similar preserve effects on the cartilage glucosaminoglycan compositions in this experiment.
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KEYWORD
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Rheumatoid arthritis, Freund`s complete aduvant, FCA, Samki-eum, sanqi-yin
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